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The longest of the trials (SURMOUNT-4) reported weight loss of -20.9% within 36 weeks and an additional -5.5% (total of -25.4%) within 88 weeks of administration [20]

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In the formal clinical trial reports for retatrutide, alopecia did not appear as a common side effect

Instead, were hearing things like: Ive lost weight, but now I feel weak. I cant lift like I used to. Should I be taking something for my muscles? These comments are showing up most in patients over 50 or those using GLP-1s outside of a supervised weight loss program

Research characterizes its modulation of the nitric oxide system and promotion of angiogenesis upregulating VEGF signaling and supporting endothelial function as a unifying mechanism linking its diverse tissue-repair effects 5